Im More Excited Because I Am Re-purposing This Drug, She Said.

Clouded vision caused by cataracts can make it more difficult to read, drive a car especially at night or see the expression on a friend’s face. There he was involved in research in radiation biology and received the husking Scholarship. The surgery has a high rate of complications. On the other hand, a sub capsular cataract may not produce any symptoms until it’s well-developed. No one knows for sure why the eye’s lens changes as we age, forming cataracts. The clouding of this lens during cataract formation distorts vision. The type of cataract you have will affect exactly which symptoms you experience and how soon they will occur. The retina works by converting the light that comes through the lens into signals.

Shruti Sharma of the Center for Biotechnology and Genomic Medicine has a $1.5 million grant from the National Eye Institute to look at basic research into blocking inflammation among epithelial cells in light-sensing retina in the eye, Sharma is looking at a well-known agent in inflammation called interleukin-6 that can affect those cells even though they lack the receptor normally needed for such interaction, an effect called trans-signaling. While that effect had been known for a while it is not something that researchers had focused on in the past, she said. Sharma is looking at an experimental drug that in her early work seems to have blocked that type of action in those cells, using it both in the lab in human cells in the same kind of environment that is there in the eye and in a mouse model of diabetes. The hope is to prevent the barrier disruption to the cells that can cause them to become leaky and create inflammation, an early hallmark of the disease. The mouse model allows Sharma to test the compound in both late and early stages of the disease to see if it she can prevent diabetic retinopathy from happening, she said. Getting Advice On Swift Products In Eye Surgery | Suggestions For The EyeballsSeparately, the compound is being tested in human clinical trials in rheumatoid arthritis, which is also promising, Sharma said. Im more excited because I am re-purposing this drug, she said. I am not trying to develop a new drug. The Best Questions For Deciding Upon Details In Eye Surgery | Advice To The ViewBut that potential is why Augusta University has translational programs to try and bring those promising research ideas to the clinic, said Nussbaum , chair of the Department of Ophthalmology. And it is a big problem to address – there are at least 4.2 million people with diabetic retinopathy in the U.S., according to the American Diabetes Association. Diabetes affected 9.1 percent of people in the U.S. in 2014 and it is even higher in the Augusta area, with 13.5 percent affected in Richmond County and some surrounding counties above 17 percent.

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