But drinking the same bottle year in, year out is no answer. Lettie Teague shares strategies to help get drinkers out of their wine ruts By Lettie.Teague@wsj.com Updated Nov. 23, 2016 3:43 p.m. ET DOCTORS ARE thought to be highly rational women and men. Yet my friend Allen, a plastic surgeon, loves Napa Valley Cabernet with an ungovernable passion. No matter the occasion, the company or the context, Napa Cabernet is his drink of choice. Ive tried to introduce Allen to other wines, and while he claims each time to enjoy them, by our next dinner hes reverted to type. Convincing a friend to try different wines once hes found a style, a region or even a producer that particularly resonates is no small matter. For…
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In a study published today in the journal Current Biology, Texas A&M College of Medicine researchers demonstrate that mitochondria, the so-called powerhouses of the cell, play a crucial role in a tumor’s ability to grow. With a better understanding of how this process is regulated, new targets for cancer treatments could be identified. Mitochondria, the organelles inside each cell that generate energy, play a crucial role in a tumor’s ability to generate the energy needed to invade healthy tissue. Mitochondria exhibit a remarkable ability to change theirshape and spatial distribution within a cell, said Raquel Sitcheran, PhD, assistant professor at the Texas College of Medicine and corresponding author of the study. foot pain lupusWe uncovered a surprising new regulator of mitochondrial dynamics that is important for promoting cancer cell invasion. This regulator, which is called NIK, is a protein that regulates immune cell function and inflammation. Their new finding is that NIK is also present on mitochondria in brain, pancreatic and breast cancer cells. When the research team removed all NIK expression using CRISPR -Cas9 genome editing, the cancer cells were no longer able to invade. On the other hand, NIK is upregulated when a cell becomes cancerous, and the more invasive tumors had higher activation of the NIK pathway. In cancer cells, mitochondria typically undergo fission and are small in size, allowing them to move rapidly to areas of the cell with high energy demandsusually the branches of a cell that are invading surrounding tissue. Without NIK, the mitochondria become fused and are impaired in their ability to move efficiently to areas of the cell that initiate and drive the process of invasion. Theres a link between NIK, mitochondrial function and cancer cell invasion, Sitcheran said.
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